Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray two young scientists and lovers who begin involving human DNA in their splicing of animal genes.


Superstar genetic engineers Clive Nicoli and Elsa Kast achieve fame by successfully splicing together the DNA of different animals, to create incredible new hybrid animals. Now they want to use human DNA in a hybrid that could revolutionize science and medicine. But when the pharmaceutical company that funds their research forbids it, Clive and Elsa secretly conduct their own experiments in the pursuit of even greater scientific discovery. They secretly blend human DNA with their creations, ignoring their society's ethical and legal boundaries.

The scientists name their creature Dren, and Dren exceeds their wildest dreams, she begins to grow and learn at an accelerated rate. As their lab becomes exceedingly crowded, and the risk of Dren being discovered increases, they move Dren to Elsa's dead mother's farm. There Clive discovers that Elsa used her own DNA to create the creature, which by now has become amphibious, winged and omnivorous with a toxic sting. The two must come to terms with their decision as their creature quickly develops into a deadly, winged humanoid monster.


On June 4th... Meet Dren.

Science's Newest Miracle ... Is A Mistake

She's Not Human ... Not Entirely.

The Future Is Born 06.04.2010


  • Adrien Brody as Clive Nicoli
  • Sarah Polley as Elsa Kast
  • Delphine Chanéac as Dren
  • David Hewlett as Barlow
  • Abigail Chu as Young Dren
  • Brandon McGibbon as Gavin Nicoli
  • Stephanie Baird as Elsa / PD


  • Clive and Elsa's names are an homage to Bride Of Frankenstein (1935). Colin Clive played Dr. Henry Frankenstein while Elsa Lanchester played Mary Wollstonecraft Shelley/The Bride.